This technical note shares experiences and lessons learned from two international NGOs working with local partners to deliver microfinance and microenterprise development services to clients affected by HIV and AIDS. The two cases examined here, CHF International and Catholic Relief Services, are both international NGOs operating in Rwanda and participants in The SEEP Network Practitioner Learning Program on Building Alliances to Serve HIV and AIDS-Impacted Communities in Sub-Saharan Africa (BASICS).