This progress note is a synthesis of an on-line discussion held in April 2006, hosted by the SEEP Network’s Market Development Working Group. The on-line discussion, “Economic Support and Income-Generating Programming for HIV and AIDS–Impacted Communities,” which followed a 2004 exploratory discussion, invited broader participation from the economic development and HIV and AIDS communities of practice. Although the 64 registrants for the discussion indicated strong interest in the topic, the participation of relatively few is interpreted to reflect the limited experience in economic and income-generating programming for HIV and AIDS–impacted communities. The significant challenges discussed ranged from how to address skills loss to how community-based organizations and self-help groups can link with broader economic development initiatives, and from how to deal with the threat of violence against HIV and AIDS–support programs to how to raise funding for economic support programs in HIV/AIDS–affected communities.